THROMBOSIS AND HEMOSTASIS A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo
نویسندگان
چکیده
1Department of Pathology, Vanderbilt University, Nashville, TN; 2Division of Biomedical Engineering and Hematology/Oncology, Oregon Health and Sciences University, Portland, OR; 3Department of Pediatrics, Vanderbilt University, Nashville, TN; 4Department of Internal Medicine, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL; 5Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; and 6Department of Medicine, Vanderbilt University, Nashville, TN
منابع مشابه
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance for thrombosis in pri mates. In 2 carotid artery injury models (FeCl(3) and Rose Bengal/laser), fXII-deficient mice are more resistant to thrombosis than fXI- or fac...
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